NEOAGING SCIENCE
Magnesium: Studies, effects & scientific background
Science is our foundation: At NEOaging, we develop all our products based on current studies. Here we show you how magnesium works – scientifically sound, evidence-based, and with a focus on your healthy aging.
Use your energy source - magnesium
Magnesium is an essential mineral and cofactor in hundreds of enzymatic reactions of human metabolism. It is indispensable for energy production (ATP synthesis), DNA replication and RNA synthesis, protein synthesis, signal transduction between nerve cells, and the regulation of muscle contractions.1 Absorption occurs primarily in the small intestine, with bioavailability depending strongly on the magnesium compound (e.g., glycinate, citrate, taurate, oxide) and the overall nutritional status.
Magnesium in figures
Did you know that magnesium makes up a significant portion of your body?
There are only a few things inside your body.
Magnesium in your bones¹
A significant proportion of
is located in your musculature²
Only about
is located in the blood plasma²
Scientific findings
Magnesium's origins date back to the 1930s, when classic deficiency experiments on animals demonstrated that a deficiency triggered serious disorders. Muscle cramps, neuromuscular hyperexcitability, growth disorders, and cardiac arrhythmias were some of the manifestations.³ Between 1980 and 1990, epidemiological cohort studies investigated the importance of magnesium in relation to chronic diseases. The ARIC study found an association between low magnesium levels and an increased risk of type 2 diabetes, hypertension, insulin resistance, and accelerated vascular aging.⁴ Further studies support the assumptions that magnesium significantly reduces the development of hypertension and contributes to the maintenance of normal bone density—and could therefore also serve as a preventative measure.⁶
Magnesium in modern science
Magnesium for your longevity
Today, magnesium is increasingly recognized as a longevity factor. Recent studies show that a deficiency not only impairs energy metabolism but also promotes mitochondrial stress, DNA damage, and chronic inflammation—mechanisms closely linked to the aging process.⁷⁸⁹
A 2016 meta-analysis of 34 randomized, placebo-controlled trials showed that magnesium supplementation reduced systolic blood pressure by an average of 2 mmHg and diastolic blood pressure by 1.8 mmHg. Simultaneously, serum magnesium levels increased, confirming the biological effect of supplementation. Older individuals, those with low baseline magnesium levels, or those taking antihypertensive/diabetic medication benefited more. The results suggest a moderate but causal contribution of magnesium to blood pressure regulation.¹⁰
A 2016 meta-analysis examined the relationship between magnesium intake and long-term health risks. For every 100 mg of magnesium per day, the risk of heart failure decreased by 22%, the risk of stroke by 7%, and the risk of all-cause mortality by 10%. However, no consistent effects were found for coronary heart disease or total cardiovascular disease (CVD). This suggests that increased magnesium intake may significantly reduce the risk of some of the most serious cardiovascular complications and a shortened life expectancy.¹¹
The effect of magnesium supplementation on systemic inflammatory markers was investigated in a randomized/placebo meta-analysis (2017). Subgroup analyses revealed that magnesium significantly reduced CRP levels by an average of 1.1 mg/L in individuals with a high inflammatory status (CRP > 3 mg/L), while no effect was observed in individuals with low baseline CRP levels. This suggests that magnesium is particularly effective in existing inflammatory processes and may reduce chronic low-grade inflammation, also known as "inflammaging."¹²
A 2016 meta-analysis investigated the relationship between magnesium intake and the risk of type 2 diabetes. Comparing the highest and lowest intake categories showed a 26% lower risk of developing the disease. Furthermore, the dose-response analysis revealed that for every additional 100 mg of magnesium per day, the risk of type 2 diabetes decreased by 19%. This protective effect was particularly pronounced in studies with longer follow-up periods and in Asian populations. These findings underscore the importance of magnesium for insulin sensitivity and the regulation of glucose metabolism.¹¹
A 2017 meta-analysis showed a significant association between higher magnesium intake and a lower risk of depression. Individuals in the highest intake category had a 19% lower risk of depression compared to the lowest category. A dose-response analysis also indicated the strongest protective effect with a daily intake of approximately 320 mg of magnesium—a value close to the recommended reference intakes.1⁴
A 2022 meta-analysis examined the influence of magnesium on the bone health of older adults. The results showed that higher magnesium intake was associated with better bone mineral density in the hip and femoral neck. The data were less conclusive for other bone regions or fracture risk. The findings suggest that adequate magnesium intake may help slow age-related bone loss and reduce the risk of osteoporosis.¹³
Magnesium & the Hallmarks of Aging – More Than Just a Mineral
Magnesium plays a central role in various aging processes and directly influences several hallmarks of aging. A deficiency can impair mitochondrial function, DNA stability, protein synthesis, inflammation regulation, and tissue regeneration.
Affected Hallmarks of Aging:
What is important in NEOaging:
Highly bioavailable magnesium complex
Our Magnesium Superior offers a balanced combination of seven different magnesium compounds to ensure comprehensive nutrition. Magnesium fulfills a wide range of functions in the body and is needed for muscles¹, bones², energy³, mental functions⁴, and nerves⁵, among other things.
Dosage & Quality: What studies show about effective use
