NEOAGING SCIENCE
Omega 3: Studies, effects & scientific background
Science is our foundation: At NEOaging, we develop all our products based on current studies. Here we show you how Omega 3 works – scientifically sound, evidence-based, and with a focus on your healthy aging.
Strengthen your cells - Omega 3
Omega-3 fatty acids are among the essential nutrients that the human body cannot produce itself and therefore must obtain through diet. The two long-chain representatives, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are particularly important. They are found primarily in fatty cold-water fish such as salmon, herring, mackerel, and sardines, but can also be extracted from microalgae. At the cellular level, EPA and DHA play a key role: They are important components of biological membranes, influencing their flexibility and stability, and act as precursors for a number of signaling molecules that regulate inflammatory processes. Omega-3 fatty acids have been a central research topic in nutritional science and medicine for decades.
Omega 3 in numbers
Did you know that Omega 3 makes up a significant portion of your body?
The brain consists of up to
made of fat.¹
A significant proportion of
DHA is produced in the cerebral cortex alone.²
Only about
Europeans have an optimal Omega-3 index in their blood²
Reduced cardiovascular risk
EPA can reduce serious cardiac events by around 25%.
Scientific findings
In the late 1970s, epidemiological studies showed that Greenland Inuit had significantly lower rates of heart attacks and cardiovascular disease than people in Western industrialized countries. This was interpreted as an indication that the high consumption of marine fats—especially EPA and DHA—might have a protective effect (O'Keefe & Harris, 2000). Today, it is known that, in addition to diet, genetic adaptations, lifestyle, and environmental conditions of the Inuit also played a role (Fumagalli et al., 2015).
Building on this observation, a broad body of evidence emerged in the following decades: Intervention and cohort studies show that EPA and DHA regulate inflammation, favorably influence lipid metabolism, stabilize cell membranes, and can positively affect cardiovascular and neurological diseases. Omega-3 fatty acids are a central focus in longevity research because they address key mechanisms of aging—from reducing chronic inflammation (“inflammaging”) and protecting mitochondrial function to supporting brain and eye health. Thus, EPA and DHA remain a core element of evidence-based strategies for healthy aging.
Magnesium in modern science
Omega 3 for your longevity
Today, magnesium is increasingly recognized as a longevity factor. Recent studies show that a deficiency not only impairs energy metabolism but also promotes mitochondrial stress, DNA damage, and chronic inflammation—mechanisms closely linked to the aging process.⁷⁸⁹
The strongest evidence for the efficacy of omega-3 fatty acids comes from cardiovascular research. A large meta-analysis of 38 randomized controlled trials with over 149,000 participants showed that EPA and DHA supplementation can significantly reduce the risk of cardiovascular death, heart attack, and revascularization. The effects were particularly pronounced with high-dose EPA supplements, which achieved a reduction of approximately 25% in major cardiovascular events in several studies. It is now considered well-established that omega-3 fatty acids, especially EPA, can effectively reduce the risk of cardiovascular disease, particularly in people with elevated risk or abnormal triglyceride levels (Khan et al., 2021).
Omega-3 fatty acids such as EPA and DHA play a significant role in the structure of biological cell membranes. They influence their flexibility, stability, and the way signals are transmitted between cells. A scientific study has shown that EPA and DHA can alter the composition of membrane phospholipids, thereby influencing processes associated with communication and regulation within the cell. The research suggests that these fatty acids are involved in the formation of certain signaling molecules that modulate physiological inflammatory responses. These findings underscore the importance of omega-3 fatty acids in the context of cell health and cell membrane function.
A recent meta-analysis of 90 randomized controlled trials with nearly 73,000 participants shows that omega-3 fatty acids significantly improve the overall blood lipid profile. In particular, triglycerides and non-HDL cholesterol are reduced in a clear, dose-dependent manner, with the strongest effects at ≥2 g per day, especially in individuals with hyperlipidemia, coronary artery disease, or obesity. A non-linear relationship was observed for LDL and HDL cholesterol: while moderate amounts have a beneficial effect, very high intake can lead to a slight increase in LDL. Regarding the differentiation between the two main forms: EPA and DHA lower triglycerides to a similar extent, but DHA more frequently increases LDL. At the same time, DHA appears to have a somewhat stronger overall effect on the lipid profile in people at increased risk. This provides good evidence that EPA and DHA effectively lower triglycerides and non-HDL cholesterol, with DHA being distinguished by stronger, but also more complex effects on LDL (Wang et al., 2023).
A comprehensive umbrella meta-analysis of 32 meta-analyses investigated the influence of omega-3 fatty acids on inflammatory biomarkers in adults with varying health conditions. The results show a consistent reduction in key inflammatory markers: C-reactive protein (CRP) decreased significantly (effect size −0.40), as did tumor necrosis factor-alpha (TNF-α) (−0.23) and interleukin-6 (IL-6) (−0.22). This is the first time a meta-analysis has demonstrated that EPA and DHA supplementation has a systemic anti-inflammatory effect. These findings underscore the importance of omega-3 fatty acids as an adjunctive, anti-inflammatory therapy. Particularly in the context of inflammaging (chronic low-grade inflammation, which promotes aging), EPA and DHA thus make a significant contribution to the prevention and delay of age-related diseases (Kavyani et al., 2022).
A comprehensive meta-analysis from 2023 summarized 19 randomized, placebo-controlled trials with a total of 4,246 patients suffering from dry eye disease (DED). The analysis suggests that regular supplementation with omega-3 fatty acids improves both subjective symptoms and objective measurements such as tear film stability (tear break-up time), tear production (Schirmer test), tear film osmolarity, and corneal color. Noticeable effects were observed particularly with long-term intake and adequate dosage, especially of EPA. Despite these positive trends, the authors emphasize that the studies are heterogeneous and differences in patient characteristics, dosage, duration, and concomitant therapies make generalization difficult. Overall, however, omega-3 is considered a promising supportive approach.
Controlled studies also exist regarding brain function. A systematic review from 2022, which included nine randomized clinical trials with a total of 1,319 participants, shows that omega-3 fatty acids (especially DHA) can improve learning and memory performance. For example, a 24-week supplementation with 900 mg of DHA per day led to a significant improvement in memory in 485 older adults. In another study with 65 older participants, 2.2 g of fish oil daily for 26 weeks increased executive functions by approximately 26%. Positive effects on reaction times and neuronal activity were also observed in younger adults. Overall, the data demonstrate that omega-3 fatty acids can support neuronal health and may play a protective role in age-related memory pathologies (Dighriri et al., 2022).
Omega 3 & the Hallmarks of Aging – More Than Just a Fatty Acid
Omega-3 fatty acids, especially EPA and DHA, directly intervene in several hallmarks of aging and have a protective effect at various levels of aging.
Affected Hallmarks of Aging:
What is important in NEOaging:
ANZEIGE
Ultra pure Epax® Omega 3 for heart¹ & brain²
Our Omega 3 Superior contains ultra-pure fish oil according to Epax® standards, with a 1,000 mg capsule from strictly controlled, sustainable fishing . The high doses of the omega-3 fatty acids EPA (400 mg) and DHA (200 mg) are important for heart¹, brain function², and vision³. Omega-3 fatty acids are important building blocks of our cell membranes. They help keep cell structure stable and functioning. Since our bodies cannot produce them on their own, it's important to consume them through our diet or high-quality supplements.
Dosage & Quality: What studies show regarding effective use
Effective dosage :
