NEOAGING SCIENCE

OPC: Studies, Effects & Scientific Background

Science is our foundation: At NEOaging, we develop all products based on current studies. Here we show you how OPC works – scientifically sound, evidence-based & with a focus on healthy aging.

Trauben in der Sonne
NEOaging Science

OPC (Oligomeric Proanthocyanidins) your natural antioxidant

Oligomeric proanthocyanidins (OPCs) are plant polyphenols. Grapes and berries are particularly rich in OPCs. They consist of short chains of so-called catechins/epicatechins. Thanks to numerous functional hydroxyl groups, OPCs can scavenge free radicals and thus dampen oxidative processes. Therefore, they are being investigated as natural antioxidants in research, nutritional supplements, and skincare, especially in the context of inflammation, vascular protection, and healthy aging. They are considered to be highly bioavailable.¹

OPC Grape Seed in Numbers

OPCs are plant-based antioxidants, primarily found in grape seeds, and belong to the group of polyphenols.

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Up to

30%

of all proanthocyanidins in grapes are found in the seeds²

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In OPC there are

2

Main Types in Grapes Dominant: Type A and B¹

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Up to

80%

antioxidant radical inhibition³

Darstellung OPC Moleküle, Verbindung Oligomere Proanthocyanidine

Scientific Findings on OPC

The scientific exploration of OPC (oligomeric proanthocyanidins) dates back to early vitamin research. Alongside vitamin C, Albert Szent-Györgyi also described "vitamin P" with a vascular-stabilizing effect, which, however, could not be clearly chemically classified.⁴ Today, it is known that "vitamin P" was another secondary plant compound (rutin). In 1947, Jack Masquelier isolated a colorless fraction from peanut skins that conveyed the described vitamin P effect. He identified its main components as oligomers of catechin and epicatechin in particular. These compounds are now referred to as OPCs.⁵ Since then, OPCs have been investigated experimentally and clinically with promising results.

OPC in Today's Science

OPC for Your Longevity

They are particularly valued for their antioxidant properties and are a common ingredient in dietary supplements, especially in the areas of lifestyle, well-aging, and longevity. OPCs are derived from plant sources such as grape seeds and belong to the group of secondary plant compounds. Nowadays, they are primarily widespread in the context of a conscious lifestyle, a balanced diet, and a holistic approach to health.

OPC Works – Research Proves It

Frau mit weicher Haut, Darstellung der Molekuele auf der Haut, NEOaging Hallmarks of Aging
NEOAGING FOCUS: HALLMARKS OF AGING

OPC & the Hallmarks of Aging – more than just a phytonutrient

OPCs (Oligomeric Proanthocyanidins) are secondary plant compounds with pronounced antioxidant properties. In the context of the Hallmarks of Aging, they are particularly associated with mechanisms such as oxidative stress and inflammatory regulation. As a result, they simultaneously affect several central biological aging processes and are discussed as a possible modulating factor within age-associated molecular changes.

Affected Hallmarks of Aging:

  • Mitochondrial Dysfunction: OPCs act as antioxidants, reducing lipid peroxidation and oxidized LDL⁸'⁹ → fewer ROS-related mitochondrial damages, potentially better energy homeostasis.
  • Loss of Proteostasis: Due to the antioxidant activity of OPCs³'⁹, a reduction in oxidative protein modifications is conceivable → potentially less misfolding and aggregate formation.
  • Chronic Inflammation: Lowering of hs-CRP ¹⁰ and possible dampening of inflammatory signaling pathways such as NF-κB.¹²
  • Genomic Instability: Possible reduction of oxidative DNA damage through ROS reduction ³'⁹'⁷ → less accumulation of mutations and DNA strand breaks.
OPC Traubenkern, Substanz im Reagenzglas NEOaging wissenschafltiche Erkenntnisse

What is important in NEOaging:

  • Raw material quality: OPCs are considered to be highly bioavailable, with absorption and metabolism depending, among other things, on their structure and the quality of the extract used. The best study data is available for standardized, OPC-rich grape seed extracts. Therefore, we use a tested and clearly defined standardized raw material.
  • Quality dosage:
    323 mg OPC from grape seed extract
  • Coordinated combination: The combination with vitamin C not only builds on historical research into vascular function ("Vitamin P"), but also takes into account its established role in the antioxidant network.
  • Active ingredient quality: After oral administration, OPCs are partly absorbed directly in the small intestine, and partly converted into bioactive metabolites by intestinal microbiota. Absorbed compounds are further processed in the liver and distributed systemically. In preclinical and clinical studies, standardized OPC extracts are considered well-tolerated and show no evidence of relevant toxicity.
  • Neutral taste: Pleasant to take, without burping.
Astaxanthin Wissenschaft, Hand mit schwebenden Partikeln und Molekülen
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What Studies Show About the Effective Use of OPC

  • Recommended dose: 323 mg daily
  • Insulin levels & insulin resistance: Individual studies showed positive effects at 100 mg daily
  • Blood pressure & heart rate: Consistent positive effects were observed in the range of 150–300 mg daily.
  • LDL cholesterol, triglycerides, and partially on inflammatory markers & oxidative stress: Effects predominantly occurred in the range of 200–300 mg daily.

Maximum dosage:

  • Taking high amounts over a long period has been sparsely studied. There are only isolated studies that suggest a dosage of 400 mg or more per day.

Form of administration:

  • Taken with a meal: Improved tolerability.

Studies Evidence